Anti-p57Kip2/CDKN1C Antibody (Clone#17C19)

Rabbit monoclonal antibody

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筛选器： All WB IHC ICC/IF IP

BM4129

50μl ￥1280 100μl ￥2180 150μl ￥2800
货期：现货

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Western blot analysis on HeLa cell using p57 Kip2 Antibody.
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Immunohistochemical analysis of paraffin-embedded rat kidney, using p57 Kip2 Antibody .
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Immunohistochemical analysis of paraffin-embedded Human tongue cancer, using the Antibody.
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Immunohistochemical analysis of paraffin-embedded Human thyroid cancer, using the Antibody.
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Immunohistochemical analysis of paraffin-embedded Human ovarian cancer, using the Antibody.
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Immunofluorescent analysis of HeLa cells treated with dexamethasone, using p57 Kip2 Antibody .
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产品简介>

产品名称

Anti-p57Kip2/CDKN1C Antibody (Clone#17C19)

规格/价格

50μl|1280 100μl|2180 150μl|2800

指标别称

BWCR; BWS; CDKN1C; KIP2; p57; p57Kip2; WBS

产品类型

Monoclonal

检验物种

human, mouse, rat

应用范围

WB, IHC, ICC/IF, IP

基因名称

CDKN1C

克隆号

17C19

宿主

Rabbit

抗体亚型

IgG

免疫原

A synthesized peptide derived from human p57 Kip2

计算分子量

32 kDa

实际分子量

30 kDa/57 kDa

成分

500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol.

纯化方式

Affinity-chromatography

浓度

500ug/ml

产品形态

Liquid

保存条件

12 months from date of receipt，-20℃ as supplied.

背景资料

p27 Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of p27 are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of p27 can be induced by treatment with interleukin-2 or other mitogens; this involves phosphorylation of p27 and its degradation by the ubiquitin-proteasome pathway (1-4).p57 Kip2 (Cyclin-dependent kinase inhibitor 1C) functions as a tumor suppressor. Mutations of p57 Kip2 have been associated with numerous human malignancies as well as Beckwith–Wiedemann syndrome (BWS), characterized by an increased risk of childhood cancer.

Uniprot ID

P49918

文献引用格式

p57Kip2/CDKN1C Antibody (Clone#17C19) (Boster Biological Technology, Wuhan, China. Catalog#BM4129)

应用释义

WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;

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