Anti-Glutamate receptor 2/GRIA2 Antibody (Clone#ACIB-7)

Rabbit monoclonal antibody

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筛选器： All WB IHC ICC/IF IP

BM5334

50μl ￥1280 100μl ￥2180 150μl ￥2800
货期：现货

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Western blot analysis of anti-GLUR2 antibody (BM5334). The sample well of each lane was loaded with 30 ug of sample under reducing conditions.
Lane 1: rat brain tissue lysates,
Lane 2: mouse brain tissue lysates.
After electrophoresis, proteins were transferred to a membrane. Then the membrane was incubated with rabbit anti-GLUR2 antigen affinity purified monoclonal antibody (BM5334) at a dilution of 1:1000 and probed with a goat anti-rabbit IgG-HRP secondary antibody (Catalog # BA1054). The signal is developed using ECL Plus Western Blotting Substrate (Catalog # AR1197). A specific band was detected for GLUR2 at approximately 99 kDa. The expected band size for GLUR2 is at 99 kDa.
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IHC analysis of GLUR2 using anti-GLUR2 antibody (BM5334).
GLUR2 was detected in a paraffin-embedded section of mouse brain tissue. The tissue section was incubated with rabbit anti-GLUR2 Antibody (BM5334) at a dilution of 1:200 and developed using HRP Conjugated Rabbit IgG Super Vision Assay Kit (Catalog # SV0002) with DAB (Catalog # AR1027) as the chromogen.
all(8)
IHC analysis of GLUR2 using anti-GLUR2 antibody (BM5334).
GLUR2 was detected in a paraffin-embedded section of mouse brain tissue. The tissue section was incubated with rabbit anti-GLUR2 Antibody (BM5334) at a dilution of 1:200 and developed using HRP Conjugated Rabbit IgG Super Vision Assay Kit (Catalog # SV0002) with DAB (Catalog # AR1027) as the chromogen.
all(8)
IHC analysis of GLUR2 using anti-GLUR2 antibody (BM5334).
GLUR2 was detected in a paraffin-embedded section of pig brain tissue. The tissue section was incubated with rabbit anti-GLUR2 Antibody (BM5334) at a dilution of 1:200 and developed using HRP Conjugated Rabbit IgG Super Vision Assay Kit (Catalog # SV0002) with DAB (Catalog # AR1027) as the chromogen.
all(8)
IHC analysis of GLUR2 using anti-GLUR2 antibody (BM5334).
GLUR2 was detected in a paraffin-embedded section of rat brain tissue. The tissue section was incubated with rabbit anti-GLUR2 Antibody (BM5334) at a dilution of 1:200 and developed using HRP Conjugated Rabbit IgG Super Vision Assay Kit (Catalog # SV0002) with DAB (Catalog # AR1027) as the chromogen.
all(8)
IHC analysis of GLUR2 using anti-GLUR2 antibody (BM5334).
GLUR2 was detected in a paraffin-embedded section of rat brain tissue. The tissue section was incubated with rabbit anti-GLUR2 Antibody (BM5334) at a dilution of 1:200 and developed using HRP Conjugated Rabbit IgG Super Vision Assay Kit (Catalog # SV0002) with DAB (Catalog # AR1027) as the chromogen.
all(8)
all(8)
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产品简介>

产品名称

Anti-Glutamate receptor 2/GRIA2 Antibody (Clone#ACIB-7)

规格/价格

50μl|1280 100μl|2180 150μl|2800

指标别称

GluA2; GluR 2; GluR B; GluR K2; GLUR2; GLURB; Glutamate receptor 2; GRIA2; HBGR2

产品类型

Monoclonal

检验物种

human, mouse, rat, pig

应用范围

WB, IHC, ICC/IF, IP

基因名称

GRIA2

克隆号

ACIB-7

宿主

Rabbit

抗体亚型

IgG

免疫原

A synthesized peptide derived from human GluR2 Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

计算分子量

99 kDa

实际分子量

99 kDa

成分

500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol.

纯化方式

Affinity-chromatography

浓度

500 ug/ml

产品形态

Liquid

保存条件

12 months from date of receipt，-20℃ as supplied.

背景资料

Glutamate receptor 2, also known as GLUR2, is a protein that in humans is encoded by the GRIA2 gene. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. GLUR2's cytogenetic location is 4q32.1. The crystal structures of the GLUR2 ligand-binding core in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPA and glutamate.GLUR2 plays a major role in depression at synapses in which glutamate remains in the synaptic cleft for prolonged periods of time during normal operation of the synapse. The overexpression of GLUR2 increases dendritic spine size and density in hippocampal neurons, and more remarkably, induces spine formation in GABA-releasing interneurons that normally lack spines.

Uniprot ID

P42262

文献引用格式

Glutamate receptor 2/GRIA2 Antibody (Clone#ACIB-7) (Boster Biological Technology, Wuhan, China. Catalog#BM5334)

应用释义

WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;

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